Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2648140..2649728 Replicon chromosome
Accession NZ_CP104796
Organism Klebsiella pneumoniae strain GX34

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag N7T97_RS13725 Protein ID WP_023301940.1
Coordinates 2648140..2649462 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag N7T97_RS13730 Protein ID WP_002904790.1
Coordinates 2649462..2649728 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7T97_RS13710 (2643196) 2643196..2645697 + 2502 WP_040182042.1 fimbria/pilus outer membrane usher protein -
N7T97_RS13715 (2645685) 2645685..2646689 + 1005 WP_009308876.1 fimbrial protein -
N7T97_RS13720 (2646831) 2646831..2648123 + 1293 WP_016946381.1 glycoside hydrolase family 10 protein -
N7T97_RS13725 (2648140) 2648140..2649462 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
N7T97_RS13730 (2649462) 2649462..2649728 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N7T97_RS13735 (2649994) 2649994..2650320 - 327 WP_004143476.1 hydroxyisourate hydrolase -
N7T97_RS13740 (2650317) 2650317..2650817 - 501 WP_048289870.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N7T97_RS13745 (2650795) 2650795..2652174 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
N7T97_RS13750 (2652520) 2652520..2653674 + 1155 WP_040182036.1 FAD-dependent urate hydroxylase HpxO -
N7T97_RS13755 (2653655) 2653655..2654578 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2450862..2683397 232535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T259196 WP_023301940.1 NZ_CP104796:c2649462-2648140 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT259196 WP_002904790.1 NZ_CP104796:c2649728-2649462 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References