Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 787260..787917 Replicon chromosome
Accession NZ_CP104796
Organism Klebsiella pneumoniae strain GX34

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag N7T97_RS04270 Protein ID WP_002916310.1
Coordinates 787507..787917 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag N7T97_RS04265 Protein ID WP_002916312.1
Coordinates 787260..787526 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7T97_RS04240 (782416) 782416..783849 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
N7T97_RS04245 (783968) 783968..784696 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
N7T97_RS04250 (784746) 784746..785057 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
N7T97_RS04255 (785221) 785221..785880 + 660 WP_002916317.1 hemolysin III family protein -
N7T97_RS04260 (786031) 786031..787014 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
N7T97_RS04265 (787260) 787260..787526 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
N7T97_RS04270 (787507) 787507..787917 + 411 WP_002916310.1 protein YgfX Toxin
N7T97_RS04275 (787924) 787924..788445 - 522 WP_004144730.1 flavodoxin FldB -
N7T97_RS04280 (788546) 788546..789442 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
N7T97_RS04285 (789465) 789465..790178 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N7T97_RS04290 (790184) 790184..791917 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T259191 WP_002916310.1 NZ_CP104796:787507-787917 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT259191 WP_002916312.1 NZ_CP104796:787260-787526 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References