Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2873881..2874595 Replicon chromosome
Accession NC_016804
Organism Mycobacterium bovis BCG str. Mexico

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag BCGMEX_RS13435 Protein ID WP_003413460.1
Coordinates 2874155..2874595 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag BCGMEX_RS13430 Protein ID WP_003413456.1
Coordinates 2873881..2874168 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGMEX_RS13395 2869313..2869558 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
BCGMEX_RS13400 2869555..2869959 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
BCGMEX_RS13405 2870176..2870796 + 621 WP_003413441.1 DUF4178 domain-containing protein -
BCGMEX_RS13410 2870807..2871301 + 495 WP_003413444.1 DUF2617 family protein -
BCGMEX_RS13415 2871298..2871729 + 432 WP_003413445.1 DUF4247 domain-containing protein -
BCGMEX_RS13420 2871754..2872202 + 449 Protein_2614 DUF350 domain-containing protein -
BCGMEX_RS13425 2872199..2873770 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
BCGMEX_RS13430 2873881..2874168 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
BCGMEX_RS13435 2874155..2874595 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
BCGMEX_RS13440 2874616..2875371 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
BCGMEX_RS13445 2875504..2876100 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
BCGMEX_RS13450 2876108..2876953 - 846 WP_010950749.1 acyl-CoA thioesterase II -
BCGMEX_RS13455 2876982..2877881 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
BCGMEX_RS13460 2878009..2878683 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T25919 WP_003413460.1 NC_016804:2874155-2874595 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T25919 NC_016804:2874155-2874595 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT25919 WP_003413456.1 NC_016804:2873881-2874168 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT25919 NC_016804:2873881-2874168 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References