Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 42775..43376 Replicon plasmid pHNSHP24-3
Accession NZ_CP104791
Organism Escherichia coli strain SHP24

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag N6H17_RS26390 Protein ID WP_001216034.1
Coordinates 42775..43155 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag N6H17_RS26395 Protein ID WP_001190712.1
Coordinates 43155..43376 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H17_RS26360 (N6H17_26370) 37875..37994 - 120 WP_071594056.1 ash family protein -
N6H17_RS26365 (N6H17_26375) 38216..39700 - 1485 WP_096321054.1 terminase -
N6H17_RS26370 (N6H17_26380) 39700..40893 - 1194 WP_096321055.1 terminase -
N6H17_RS26375 (N6H17_26385) 40979..41431 - 453 WP_001326849.1 late promoter-activating protein -
N6H17_RS26380 (N6H17_26390) 41520..42563 - 1044 WP_009446825.1 DUF968 domain-containing protein -
N6H17_RS26385 (N6H17_26395) 42591..42770 - 180 WP_001339207.1 hypothetical protein -
N6H17_RS26390 (N6H17_26400) 42775..43155 - 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
N6H17_RS26395 (N6H17_26405) 43155..43376 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N6H17_RS26400 (N6H17_26410) 43559..45115 + 1557 WP_112917413.1 type I restriction-modification system subunit M -
N6H17_RS26405 (N6H17_26415) 45112..46317 + 1206 WP_001293319.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-1.1 - 1..99354 99354


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T259187 WP_001216034.1 NZ_CP104791:c43155-42775 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT259187 WP_001190712.1 NZ_CP104791:c43376-43155 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References