Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 176137..176762 Replicon plasmid pHNSHP24-2
Accession NZ_CP104790
Organism Escherichia coli strain SHP24

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N6H17_RS26110 Protein ID WP_000911313.1
Coordinates 176137..176535 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2X7GCP6
Locus tag N6H17_RS26115 Protein ID WP_000450528.1
Coordinates 176535..176762 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H17_RS26090 (172310) 172310..172915 + 606 WP_261629686.1 conjugal transfer pilus-stabilizing protein TraP -
N6H17_RS26100 (173604) 173604..173888 + 285 Protein_185 hypothetical protein -
N6H17_RS26105 (173939) 173939..176128 + 2190 WP_261629687.1 type IV conjugative transfer system coupling protein TraD -
N6H17_RS26110 (176137) 176137..176535 - 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
N6H17_RS26115 (176535) 176535..176762 - 228 WP_000450528.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - pic 1..186621 186621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T259184 WP_000911313.1 NZ_CP104790:c176535-176137 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8562.62 Da        Isoelectric Point: 4.7513

>AT259184 WP_000450528.1 NZ_CP104790:c176762-176535 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X7GCP6

References