Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 95028..95587 Replicon plasmid pHNSHP24-2
Accession NZ_CP104790
Organism Escherichia coli strain SHP24

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N6H17_RS25610 Protein ID WP_000421255.1
Coordinates 95028..95303 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N6H17_RS25615 Protein ID WP_001487904.1
Coordinates 95303..95587 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H17_RS25600 (90121) 90121..93945 - 3825 WP_064759636.1 S6 family peptidase -
N6H17_RS25605 (94518) 94518..94958 - 441 WP_001290069.1 hypothetical protein -
N6H17_RS25610 (95028) 95028..95303 - 276 WP_000421255.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N6H17_RS25615 (95303) 95303..95587 - 285 WP_001487904.1 ribbon-helix-helix domain-containing protein Antitoxin
N6H17_RS25620 (95872) 95872..96261 + 390 Protein_89 recombinase family protein -
N6H17_RS25630 (97510) 97510..99059 - 1550 Protein_91 type IV secretion system DNA-binding domain-containing protein -
N6H17_RS25635 (99114) 99114..99791 + 678 WP_001339397.1 IS66-like element accessory protein TnpA -
N6H17_RS25640 (99791) 99791..100138 + 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - pic 1..186621 186621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10718.42 Da        Isoelectric Point: 9.9324

>T259181 WP_000421255.1 NZ_CP104790:c95303-95028 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRIGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10554.04 Da        Isoelectric Point: 6.2191

>AT259181 WP_001487904.1 NZ_CP104790:c95587-95303 [Escherichia coli]
MKMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNHLTLEALDDVTSGQVIDHQAVQRW
ADSLGTDEPLPLPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References