Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 55377..55912 Replicon plasmid pHNSHP24-2
Accession NZ_CP104790
Organism Escherichia coli strain SHP24

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N6H17_RS25440 Protein ID WP_000222773.1
Coordinates 55625..55912 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8H9KB11
Locus tag N6H17_RS25435 Protein ID WP_001132891.1
Coordinates 55377..55628 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H17_RS25415 (51404) 51404..51484 - 81 Protein_48 hypothetical protein -
N6H17_RS25420 (51472) 51472..52377 + 906 Protein_49 IS3 family transposase -
N6H17_RS25425 (52727) 52727..53893 + 1167 WP_000523852.1 plasmid-partitioning protein SopA -
N6H17_RS25430 (53893) 53893..54864 + 972 WP_000817026.1 ParB/RepB/Spo0J family plasmid partition protein -
N6H17_RS25435 (55377) 55377..55628 + 252 WP_001132891.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N6H17_RS25440 (55625) 55625..55912 + 288 WP_000222773.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N6H17_RS25445 (56048) 56048..56442 + 395 Protein_54 helix-turn-helix domain-containing protein -
N6H17_RS25450 (56631) 56631..57679 - 1049 Protein_55 transposase -
N6H17_RS25455 (57695) 57695..58368 - 674 Protein_56 transposase -
N6H17_RS25460 (58441) 58441..58839 + 399 Protein_57 conjugal transfer protein TraD -
N6H17_RS25465 (58848) 58848..59246 - 399 WP_096973166.1 type II toxin-antitoxin system VapC family toxin -
N6H17_RS25470 (59246) 59246..59473 - 228 WP_000450530.1 toxin-antitoxin system antitoxin VapB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - pic 1..186621 186621
- inside IScluster/Tn - - 46301..58368 12067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11221.29 Da        Isoelectric Point: 10.5832

>T259179 WP_000222773.1 NZ_CP104790:55625-55912 [Escherichia coli]
MTYTVKFRDDALKEWMKLDKSIQQQFAKKLKKCSENPHIPSAKLRELKNCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERNNVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9181.39 Da        Isoelectric Point: 4.0780

>AT259179 WP_001132891.1 NZ_CP104790:55377-55628 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVGAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References