Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 1777..2534 Replicon plasmid pHNSHP24-2
Accession NZ_CP104790
Organism Escherichia coli strain SHP24

Toxin (Protein)


Gene name tacT Uniprot ID A0A0L6ZF90
Locus tag N6H17_RS25185 Protein ID WP_000501972.1
Coordinates 2049..2534 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag N6H17_RS25180 Protein ID WP_072141942.1
Coordinates 1777..2061 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H17_RS25175 (1) 1..858 + 858 WP_195686735.1 incFII family plasmid replication initiator RepA -
N6H17_RS25180 (1777) 1777..2061 + 285 WP_072141942.1 DUF1778 domain-containing protein Antitoxin
N6H17_RS25185 (2049) 2049..2534 + 486 WP_000501972.1 GNAT family N-acetyltransferase Toxin
N6H17_RS25190 (3154) 3154..4256 - 1103 Protein_3 transposase -
N6H17_RS25195 (4256) 4256..4621 - 366 WP_032233136.1 hypothetical protein -
N6H17_RS25200 (4893) 4893..5408 - 516 WP_000419088.1 YopT-type cysteine protease domain-containing protein -
N6H17_RS25205 (5570) 5570..6607 + 1038 Protein_6 IS21 family transposase -
N6H17_RS25210 (6607) 6607..7404 + 798 WP_053295843.1 IS21-like element IS21 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - pic 1..186621 186621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-150)

Antitoxin

Vibrio phage ICP1, Orf50

(7-93)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17630.39 Da        Isoelectric Point: 9.9107

>T259178 WP_000501972.1 NZ_CP104790:2049-2534 [Escherichia coli]
MGCVTAPEPLSSFHQVAEFVSGEAVLDDWLKQKGLKNQALGATRTFVVCRKGTQQVVGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDASFRGKGLGADLLHDAVRRCYRVAENIGVRAIMVHALTESAKQFYIHHGFTPSKTQLQTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10973.61 Da        Isoelectric Point: 4.5625

>AT259178 WP_072141942.1 NZ_CP104790:1777-2061 [Escherichia coli]
MIYGGFMKSDVQLNLRARESQRILIDTAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDRQYEEFIEMLDAPVADEP
AIEKLLARKPQWDV

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L6ZF90

Antitoxin

Source ID Structure

References