Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3355381..3356213 Replicon chromosome
Accession NZ_CP104788
Organism Escherichia coli strain SHP24

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag N6H17_RS16525 Protein ID WP_000854816.1
Coordinates 3355839..3356213 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag N6H17_RS16520 Protein ID WP_001285402.1
Coordinates 3355381..3355749 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H17_RS16490 (3352018) 3352018..3352473 + 456 WP_000581504.1 IrmA family protein -
N6H17_RS16495 (3352552) 3352552..3352707 + 156 WP_042960768.1 DUF905 family protein -
N6H17_RS16500 (3352876) 3352876..3353694 + 819 WP_001234639.1 DUF932 domain-containing protein -
N6H17_RS16505 (3353957) 3353957..3354436 + 480 WP_000706981.1 antirestriction protein -
N6H17_RS16510 (3354452) 3354452..3354928 + 477 WP_001487922.1 RadC family protein -
N6H17_RS16515 (3354997) 3354997..3355218 + 222 WP_000692323.1 DUF987 domain-containing protein -
N6H17_RS16520 (3355381) 3355381..3355749 + 369 WP_001285402.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N6H17_RS16525 (3355839) 3355839..3356213 + 375 WP_000854816.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
N6H17_RS16530 (3356210) 3356210..3356701 + 492 WP_000976865.1 DUF5983 family protein -
N6H17_RS16535 (3356721) 3356721..3356918 + 198 WP_000772027.1 DUF957 domain-containing protein -
N6H17_RS16540 (3357003) 3357003..3357845 + 843 WP_001274564.1 DUF4942 domain-containing protein -
N6H17_RS16545 (3358126) 3358126..3358662 - 537 WP_000942785.1 GspM family type II secretion system protein YghD -
N6H17_RS16550 (3358706) 3358706..3360109 - 1404 Protein_3232 inorganic phosphate transporter PitB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14045.05 Da        Isoelectric Point: 9.1493

>T259171 WP_000854816.1 NZ_CP104788:3355839-3356213 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLSRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13883.62 Da        Isoelectric Point: 6.3165

>AT259171 WP_001285402.1 NZ_CP104788:3355381-3355749 [Escherichia coli]
VSDTHHETNYPDDYNNRPWWGLPCTITPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELILTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References