Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3220439..3221093 Replicon chromosome
Accession NZ_CP104788
Organism Escherichia coli strain SHP24

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag N6H17_RS15835 Protein ID WP_000244777.1
Coordinates 3220439..3220846 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N6H17_RS15840 Protein ID WP_000354046.1
Coordinates 3220827..3221093 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H17_RS15815 (3216396) 3216396..3218129 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
N6H17_RS15820 (3218135) 3218135..3218845 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N6H17_RS15825 (3218870) 3218870..3219766 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N6H17_RS15830 (3219878) 3219878..3220399 + 522 WP_001055874.1 flavodoxin FldB -
N6H17_RS15835 (3220439) 3220439..3220846 - 408 WP_000244777.1 protein YgfX Toxin
N6H17_RS15840 (3220827) 3220827..3221093 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N6H17_RS15845 (3221336) 3221336..3222316 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
N6H17_RS15850 (3222512) 3222512..3223171 - 660 WP_000250274.1 hemolysin III family protein -
N6H17_RS15855 (3223335) 3223335..3223646 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
N6H17_RS15860 (3223691) 3223691..3225124 + 1434 WP_001573179.1 6-phospho-beta-glucosidase BglA -
N6H17_RS15865 (3225181) 3225181..3225924 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T259170 WP_000244777.1 NZ_CP104788:c3220846-3220439 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT259170 WP_000354046.1 NZ_CP104788:c3221093-3220827 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References