Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1638286..1638924 Replicon chromosome
Accession NZ_CP104788
Organism Escherichia coli strain SHP24

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N6H17_RS08185 Protein ID WP_000813794.1
Coordinates 1638286..1638462 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N6H17_RS08190 Protein ID WP_001270286.1
Coordinates 1638508..1638924 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H17_RS08165 (1635018) 1635018..1635080 - 63 Protein_1592 benzoate transporter -
N6H17_RS08170 (1635172) 1635172..1635708 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N6H17_RS08175 (1635781) 1635781..1637742 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N6H17_RS08180 (1637834) 1637834..1638064 - 231 WP_000494244.1 YncJ family protein -
N6H17_RS08185 (1638286) 1638286..1638462 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N6H17_RS08190 (1638508) 1638508..1638924 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N6H17_RS08195 (1639003) 1639003..1640409 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
N6H17_RS08200 (1640654) 1640654..1641799 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
N6H17_RS08205 (1641817) 1641817..1642830 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
N6H17_RS08210 (1642831) 1642831..1643772 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T259161 WP_000813794.1 NZ_CP104788:1638286-1638462 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT259161 WP_001270286.1 NZ_CP104788:1638508-1638924 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References