Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 530095..530713 Replicon chromosome
Accession NZ_CP104788
Organism Escherichia coli strain SHP24

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N6H17_RS02555 Protein ID WP_001291435.1
Coordinates 530095..530313 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N6H17_RS02560 Protein ID WP_000344800.1
Coordinates 530339..530713 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H17_RS02520 (525384) 525384..525956 + 573 WP_000779838.1 YbaY family lipoprotein -
N6H17_RS02525 (525987) 525987..526298 - 312 WP_000409911.1 MGMT family protein -
N6H17_RS02535 (526677) 526677..527030 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N6H17_RS02540 (527072) 527072..528622 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N6H17_RS02545 (528786) 528786..529256 - 471 WP_000136192.1 YlaC family protein -
N6H17_RS02550 (529372) 529372..529923 - 552 WP_000102564.1 maltose O-acetyltransferase -
N6H17_RS02555 (530095) 530095..530313 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N6H17_RS02560 (530339) 530339..530713 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N6H17_RS02565 (531259) 531259..534408 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N6H17_RS02570 (534431) 534431..535624 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T259159 WP_001291435.1 NZ_CP104788:c530313-530095 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT259159 WP_000344800.1 NZ_CP104788:c530713-530339 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References