Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4838730..4839246 Replicon chromosome
Accession NZ_CP104766
Organism Klebsiella pneumoniae strain IMT44613

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag N7Q99_RS23495 Protein ID WP_004178374.1
Coordinates 4838730..4839014 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag N7Q99_RS23500 Protein ID WP_032434351.1
Coordinates 4839004..4839246 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7Q99_RS23470 (4834213) 4834213..4834476 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
N7Q99_RS23475 (4834606) 4834606..4834779 + 174 WP_032414379.1 hypothetical protein -
N7Q99_RS23480 (4834782) 4834782..4835525 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
N7Q99_RS23485 (4835882) 4835882..4838020 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
N7Q99_RS23490 (4838262) 4838262..4838726 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N7Q99_RS23495 (4838730) 4838730..4839014 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7Q99_RS23500 (4839004) 4839004..4839246 - 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N7Q99_RS23505 (4839324) 4839324..4841234 - 1911 WP_004152270.1 PRD domain-containing protein -
N7Q99_RS23510 (4841257) 4841257..4842411 - 1155 WP_002886900.1 lactonase family protein -
N7Q99_RS23515 (4842477) 4842477..4843217 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T259150 WP_004178374.1 NZ_CP104766:c4839014-4838730 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT259150 WP_032434351.1 NZ_CP104766:c4839246-4839004 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References