Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4746002..4746705 Replicon chromosome
Accession NZ_CP104766
Organism Klebsiella pneumoniae strain IMT44613

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag N7Q99_RS23100 Protein ID WP_071994632.1
Coordinates 4746002..4746343 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag N7Q99_RS23105 Protein ID WP_032434296.1
Coordinates 4746364..4746705 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7Q99_RS23090 (4742317) 4742317..4743186 + 870 WP_023317468.1 HNH endonuclease -
N7Q99_RS23095 (4743777) 4743777..4745810 + 2034 WP_050598589.1 hypothetical protein -
N7Q99_RS23100 (4746002) 4746002..4746343 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
N7Q99_RS23105 (4746364) 4746364..4746705 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N7Q99_RS23110 (4746716) 4746716..4747258 - 543 WP_032434298.1 DNA repair protein RadC -
N7Q99_RS23115 (4747271) 4747271..4747711 - 441 WP_032434300.1 antirestriction protein -
N7Q99_RS23120 (4747742) 4747742..4748563 - 822 WP_032434301.1 DUF932 domain-containing protein -
N7Q99_RS23125 (4748683) 4748683..4749156 - 474 WP_032434303.1 hypothetical protein -
N7Q99_RS23130 (4749228) 4749228..4749680 - 453 WP_032410767.1 hypothetical protein -
N7Q99_RS23135 (4749716) 4749716..4750432 - 717 WP_032434305.1 WYL domain-containing protein -
N7Q99_RS23140 (4750676) 4750676..4751550 - 875 Protein_4533 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4734299..4779972 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T259149 WP_071994632.1 NZ_CP104766:c4746343-4746002 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT259149 WP_032434296.1 NZ_CP104766:c4746705-4746364 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References