Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2752867..2754455 Replicon chromosome
Accession NZ_CP104766
Organism Klebsiella pneumoniae strain IMT44613

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag N7Q99_RS13525 Protein ID WP_004892016.1
Coordinates 2752867..2754189 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N7Q99_RS13530 Protein ID WP_004176198.1
Coordinates 2754189..2754455 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7Q99_RS13510 (2747923) 2747923..2750424 + 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -
N7Q99_RS13515 (2750412) 2750412..2751416 + 1005 WP_032435338.1 fimbrial protein -
N7Q99_RS13520 (2751558) 2751558..2752850 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
N7Q99_RS13525 (2752867) 2752867..2754189 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
N7Q99_RS13530 (2754189) 2754189..2754455 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N7Q99_RS13535 (2754842) 2754842..2755168 - 327 WP_004184023.1 hydroxyisourate hydrolase -
N7Q99_RS13540 (2755165) 2755165..2755665 - 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N7Q99_RS13545 (2755643) 2755643..2757022 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
N7Q99_RS13550 (2757368) 2757368..2758522 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
N7Q99_RS13555 (2758503) 2758503..2759426 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T259146 WP_004892016.1 NZ_CP104766:c2754189-2752867 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT259146 WP_004176198.1 NZ_CP104766:c2754455-2754189 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References