Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2751244..2751896 Replicon chromosome
Accession NC_016804
Organism Mycobacterium bovis BCG str. Mexico

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag BCGMEX_RS12860 Protein ID WP_003412752.1
Coordinates 2751471..2751896 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag BCGMEX_RS12855 Protein ID WP_003412749.1
Coordinates 2751244..2751465 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGMEX_RS12840 2749484..2749690 - 207 WP_003899347.1 hypothetical protein -
BCGMEX_RS12845 2749826..2750449 + 624 WP_003900858.1 TIGR00725 family protein -
BCGMEX_RS12850 2750439..2751191 + 753 WP_003901416.1 hypothetical protein -
BCGMEX_RS12855 2751244..2751465 + 222 WP_003412749.1 antitoxin Antitoxin
BCGMEX_RS12860 2751471..2751896 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
BCGMEX_RS12865 2751919..2753100 - 1182 WP_010950729.1 2-oxo acid dehydrogenase subunit E2 -
BCGMEX_RS12870 2753097..2754143 - 1047 WP_010950730.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
BCGMEX_RS12875 2754154..2755257 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
BCGMEX_RS12880 2755516..2756337 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
BCGMEX_RS12885 2756334..2756891 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T25914 WP_003412752.1 NC_016804:2751471-2751896 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T25914 NC_016804:2751471-2751896 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT25914 WP_003412749.1 NC_016804:2751244-2751465 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT25914 NC_016804:2751244-2751465 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References