Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2361568..2362097 Replicon chromosome
Accession NC_016804
Organism Mycobacterium bovis BCG str. Mexico

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag BCGMEX_RS11010 Protein ID WP_003411124.1
Coordinates 2361568..2361885 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag BCGMEX_RS11015 Protein ID WP_003411127.1
Coordinates 2361882..2362097 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGMEX_RS10980 2356705..2357781 + 1077 WP_003411110.1 hypothetical protein -
BCGMEX_RS10985 2357778..2358059 + 282 WP_019283661.1 hypothetical protein -
BCGMEX_RS10990 2358095..2359168 + 1074 WP_011799246.1 quinone-dependent dihydroorotate dehydrogenase -
BCGMEX_RS10995 2359173..2359703 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
BCGMEX_RS11000 2359751..2361097 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
BCGMEX_RS11010 2361568..2361885 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BCGMEX_RS11015 2361882..2362097 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
BCGMEX_RS11020 2362352..2363410 + 1059 WP_003411129.1 hypothetical protein -
BCGMEX_RS11025 2363540..2363896 - 357 WP_003411130.1 hypothetical protein -
BCGMEX_RS11030 2363991..2364773 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
BCGMEX_RS11035 2365041..2365331 - 291 WP_003900476.1 YggT family protein -
BCGMEX_RS11040 2365493..2366149 - 657 WP_003411133.1 cell division protein SepF -
BCGMEX_RS11045 2366215..2366991 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T25913 WP_003411124.1 NC_016804:c2361885-2361568 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T25913 NC_016804:c2361885-2361568 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGACGCGTAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT25913 WP_003411127.1 NC_016804:c2362097-2361882 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT25913 NC_016804:c2362097-2361882 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References