Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 152004..153547 Replicon plasmid pGABEKP28_1
Accession NZ_CP104759
Organism Kalamiella piersonii strain GABEKP28

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N5580_RS19105 Protein ID WP_269950575.1
Coordinates 152004..153311 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5580_RS19110 Protein ID WP_120456481.1
Coordinates 153311..153547 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5580_RS19095 (N5580_19095) 147959..148360 - 402 WP_120456486.1 H-NS family nucleoid-associated regulatory protein -
N5580_RS19100 (N5580_19100) 149487..151619 + 2133 WP_269950624.1 ferric-rhodotorulic acid/ferric-coprogen receptor FhuE -
N5580_RS19105 (N5580_19105) 152004..153311 - 1308 WP_269950575.1 type II toxin-antitoxin system HipA family toxin Toxin
N5580_RS19110 (N5580_19110) 153311..153547 - 237 WP_120456481.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5580_RS19115 (N5580_19115) 153656..154978 - 1323 WP_179256413.1 glycoside hydrolase family 10 protein -
N5580_RS19120 (N5580_19120) 155064..155912 - 849 WP_120456476.1 VOC family protein -
N5580_RS19125 (N5580_19125) 155933..157069 - 1137 WP_269950625.1 amidohydrolase -
N5580_RS19130 (N5580_19130) 157066..158178 - 1113 WP_269950576.1 alkylhydroperoxidase domain protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN / pla 1..513647 513647


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-59)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48089.49 Da        Isoelectric Point: 8.3966

>T259127 WP_269950575.1 NZ_CP104759:c153311-152004 [Kalamiella piersonii]
MDQLNAWMNGERVGTLTRQKNGAHIFQYEPGWLSNPLARPLSLSLPLQYPAIASASVINFFDNLLPDNPRVRERILNRYR
AKSMQPFDLLREVGRDSVGAVMLLPVEAAAPDLSVRYEPLDAARLEKILSAYQSDIPLGMIPEERDFRISVAGAQEKTAL
LKTPQGWAVPQGPTPTSHIIKLPIGEIKQPFATLDMRDSVENEYVCLALARELGFRVPDAAIITAGKLRALAVERFDRRW
SADGARLLRLPQEDICQSLGLASATKYESDGGPGIAAIMSLLMGSSNALEDRDDFMKFQVFQWLIGATDGHAKNFSLYIE
RGGSYRLTPFYDILSAYPVLGGTGLNIRELKLAMGLTASKGKKVEIDKIFPRHFLATAASVRFSTERMTQILAFFAEAFP
AAVARVREQLPADIPPAIAEAIFSNALKMAERLSR

Download         Length: 1308 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9057.34 Da        Isoelectric Point: 10.2728

>AT259127 WP_120456481.1 NZ_CP104759:c153547-153311 [Kalamiella piersonii]
MIYSPQQLAHLIRLERQKRGWTQSDLARRVGIKQATVSNFENNPDKTTLTTLFKILQSLEQELVIQSKSTQSGKELEW

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References