Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1216559..1217184 Replicon chromosome
Accession NZ_CP104757
Organism Pectobacterium aroidearum strain QJ021

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag N5056_RS05385 Protein ID WP_005976087.1
Coordinates 1216559..1216762 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag N5056_RS05390 Protein ID WP_005976089.1
Coordinates 1216816..1217184 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5056_RS05355 (N5056_05355) 1212001..1212339 + 339 WP_002208627.1 P-II family nitrogen regulator -
N5056_RS05360 (N5056_05360) 1212377..1213663 + 1287 WP_015839357.1 ammonium transporter AmtB -
N5056_RS05365 (N5056_05365) 1213816..1214679 - 864 WP_015839358.1 acyl-CoA thioesterase II -
N5056_RS05370 (N5056_05370) 1214892..1215473 + 582 WP_181830022.1 YbaY family lipoprotein -
N5056_RS05375 (N5056_05375) 1215493..1215813 - 321 WP_015839360.1 MGMT family protein -
N5056_RS05385 (N5056_05385) 1216559..1216762 - 204 WP_005976087.1 HHA domain-containing protein Toxin
N5056_RS05390 (N5056_05390) 1216816..1217184 - 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
N5056_RS05395 (N5056_05395) 1217781..1217924 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
N5056_RS05400 (N5056_05400) 1217942..1218190 - 249 WP_181830023.1 type B 50S ribosomal protein L31 -
N5056_RS05405 (N5056_05405) 1218425..1221553 - 3129 WP_015839362.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T259117 WP_005976087.1 NZ_CP104757:c1216762-1216559 [Pectobacterium aroidearum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT259117 WP_005976089.1 NZ_CP104757:c1217184-1216816 [Pectobacterium aroidearum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References