Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 234997..235614 Replicon chromosome
Accession NZ_CP104757
Organism Pectobacterium aroidearum strain QJ021

Toxin (Protein)


Gene name hicA Uniprot ID C6DHN3
Locus tag N5056_RS01080 Protein ID WP_010281507.1
Coordinates 235435..235614 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N5056_RS01075 Protein ID WP_180779155.1
Coordinates 234997..235407 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5056_RS01060 (N5056_01060) 230822..231865 - 1044 WP_012772905.1 DNA-binding transcriptional regulator CytR -
N5056_RS01065 (N5056_01065) 232142..234340 - 2199 WP_181830192.1 primosomal protein N' -
N5056_RS01070 (N5056_01070) 234655..234870 + 216 WP_012772907.1 50S ribosomal protein L31 -
N5056_RS01075 (N5056_01075) 234997..235407 - 411 WP_180779155.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N5056_RS01080 (N5056_01080) 235435..235614 - 180 WP_010281507.1 type II toxin-antitoxin system HicA family toxin Toxin
N5056_RS01085 (N5056_01085) 235712..236722 - 1011 WP_181830191.1 iron ABC transporter permease -
N5056_RS01090 (N5056_01090) 236719..237681 - 963 WP_181830190.1 ABC transporter substrate-binding protein -
N5056_RS01095 (N5056_01095) 237691..238488 - 798 WP_181830189.1 ABC transporter ATP-binding protein -
N5056_RS01100 (N5056_01100) 238704..239021 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
N5056_RS01105 (N5056_01105) 239209..240369 + 1161 WP_012772912.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6560.69 Da        Isoelectric Point: 10.7838

>T259113 WP_010281507.1 NZ_CP104757:c235614-235435 [Pectobacterium aroidearum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14492.36 Da        Isoelectric Point: 4.3391

>AT259113 WP_180779155.1 NZ_CP104757:c235407-234997 [Pectobacterium aroidearum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLVEMGQDIPTVSTVGQLAKGSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2I1S0

Antitoxin

Source ID Structure

References