259110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 4333171..4333967 Replicon chromosome
Accession NZ_CP104755
Organism Shewanella putrefaciens strain 4H

Toxin (Protein)


Gene name - Uniprot ID A0A6N3J9I8
Locus tag N5094_RS19185 Protein ID WP_011791158.1
Coordinates 4333171..4333701 (-) Length 177 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6N3J9J2
Locus tag N5094_RS19190 Protein ID WP_011791159.1
Coordinates 4333698..4333967 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5094_RS19165 (N5094_19165) 4329442..4330209 - 768 WP_261762160.1 class I SAM-dependent methyltransferase -
N5094_RS19170 (N5094_19170) 4330489..4331262 + 774 WP_014611771.1 hypothetical protein -
N5094_RS19175 (N5094_19175) 4331537..4332007 + 471 WP_011791156.1 hypothetical protein -
N5094_RS19180 (N5094_19180) 4332070..4332762 + 693 WP_014611773.1 hypothetical protein -
N5094_RS19185 (N5094_19185) 4333171..4333701 - 531 WP_011791158.1 GNAT family N-acetyltransferase Toxin
N5094_RS19190 (N5094_19190) 4333698..4333967 - 270 WP_011791159.1 DUF1778 domain-containing protein Antitoxin
N5094_RS19195 (N5094_19195) 4334253..4335209 - 957 WP_261762161.1 hypothetical protein -
N5094_RS19200 (N5094_19200) 4335718..4336107 - 390 WP_261762162.1 GIY-YIG nuclease family protein -
N5094_RS19205 (N5094_19205) 4336118..4338253 - 2136 WP_261762163.1 S9 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19795.16 Da        Isoelectric Point: 8.3330

>T259110 WP_011791158.1 NZ_CP104755:c4333701-4333171 [Shewanella putrefaciens]
VSYSKIFKELDKSLHDRVSFDCGEAELNDFIQTQAAKHMQAGISRTMVLPAAMPLPNQKYPICSFYTIAPSSICRDTLPQ
AIGKKLPRYPIPVFLLAQLAVHKEFHGSGLGKASLIKALEYLWEINAHMRAYAIVVDCLTDQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT

Download         Length: 531 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9859.32 Da        Isoelectric Point: 4.7037

>AT259110 WP_011791159.1 NZ_CP104755:c4333967-4333698 [Shewanella putrefaciens]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATQVIAEHESVTVKADVFDQFIMACDEAKVPNKALREAA
AFTKNGEFK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N3J9I8

Antitoxin

Source ID Structure
AlphaFold DB A0A6N3J9J2

References