259104

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 1736..2337 Replicon plasmid pMGEL21054
Accession NZ_CP104754
Organism Lactiplantibacillus plantarum strain MGEL20154

Toxin (Protein)


Gene name pemK Uniprot ID Q684P1
Locus tag N5101_RS15450 Protein ID WP_001748110.1
Coordinates 1736..2080 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID Q684P2
Locus tag N5101_RS15455 Protein ID WP_003643337.1
Coordinates 2074..2337 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5101_RS15440 17..385 - 369 WP_003643339.1 hypothetical protein -
N5101_RS15445 485..1414 - 930 Protein_1 IS30 family transposase -
N5101_RS15450 1736..2080 - 345 WP_001748110.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
N5101_RS15455 2074..2337 - 264 WP_003643337.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
N5101_RS15460 2423..3010 + 588 WP_010625610.1 site-specific integrase -
N5101_RS15465 5418..5942 - 525 WP_003646143.1 hypothetical protein -
N5101_RS15470 6586..6828 - 243 WP_003643341.1 hypothetical protein -
N5101_RS15475 6915..7115 - 201 WP_003643340.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..7221 7221
- flank IS/Tn - - 641..1414 773


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-104)

Antitoxin

Antitoxin PemI-like

(8-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13041.89 Da        Isoelectric Point: 6.4782

>T259104 WP_001748110.1 NZ_CP104754:c2080-1736 [Lactiplantibacillus plantarum]
MVSQGDIFYVNFNPSRGHEQMNKRPAIALSNDLVCQTSNMTIVAPISSTKRNFPMYHRLTSSQTVYGKVLLDQTIALDLR
ARHVTDETIVDHVSREELEEIITLYKLLFSIDDK

Download         Length: 345 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10141.51 Da        Isoelectric Point: 6.4708

>AT259104 WP_003643337.1 NZ_CP104754:c2337-2074 [Lactiplantibacillus plantarum]
MELIKEQTRLAKWGNSKAARIPSQIIKQLKLDDNQDMTITIENGSIVLTPIKKNPTNIHELFKDWKDDGKRDHELDWGKS
EGNELQW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2K1X3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L4ZZT2

References