Detailed information of TA system TA259099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2297053..2298736
• Replicon: chromosome
• Accession: NZ_CP104745
• Organism: Erwinia pyrifoliae strain CP20113301

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: E3DHX2
• Locus tag: NYP80_RS11185
• Protein ID: WP_012667837.1
• Coordinates: 2297053..2297970 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: D2T9Q4
• Locus tag: NYP80_RS11190
• Protein ID: WP_012667836.1
• Coordinates: 2297963..2298736 (-)
• Length: 258 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NYP80_RS11165 (NYP80_11165)	2292863..2293672	-	810	WP_012667841.1	trehalose-phosphatase	-
NYP80_RS11170 (NYP80_11170)	2294387..2295118	+	732	WP_012667840.1	YoaK family protein	-
NYP80_RS11175 (NYP80_11175)	2295290..2295709	+	420	WP_012667839.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
NYP80_RS11180 (NYP80_11180)	2295712..2296974	+	1263	WP_012667838.1	translesion error-prone DNA polymerase V subunit UmuC	-
NYP80_RS11185 (NYP80_11185)	2297053..2297970	-	918	WP_012667837.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NYP80_RS11190 (NYP80_11190)	2297963..2298736	-	774	WP_012667836.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
NYP80_RS11195 (NYP80_11195)	2298799..2298936	+	138	Protein_2141	IS3 family transposase	-
NYP80_RS11200 (NYP80_11200)	2299221..2300198	-	978	WP_012667835.1	porphobilinogen synthase	-
NYP80_RS11205 (NYP80_11205)	2300438..2301004	+	567	WP_041473991.1	NADPH-dependent FMN reductase	-
NYP80_RS11210 (NYP80_11210)	2301099..2302433	+	1335	WP_012667833.1	cation:proton antiporter	-
NYP80_RS11215 (NYP80_11215)	2302690..2303052	-	363	WP_014538840.1	PTS galactitol transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34288.50 Da
• Isoelectric Point: 4.8381

>T259099 WP_012667837.1 NZ_CP104745:c2297970-2297053 [Erwinia pyrifoliae]
MDKQSPYYRQVALLLSALPVVAAERCFALKGGTAINLFVRDFPRLSVDIDLAYVLLESRDVALPNVRAALMRIAEILQQQ
AGISAVLQTNHSDEMRIVVSSQEAQIKIEVSPVARGTLYPPEERDIVEAVEDEFGFATIQVVSLADLYGGKLCAALDRQH
PRDFYDVKMLLETQGIDRQIFNGFITYLLGHQRPLSEVLNPRWKDISELYANEFNGMTFDAVSLEELNAIPNLMVTALKA
QFTQQDYDFLMSFKSGQPDWSLAPEDQIQHLPAVKWKLQNIGCIPKGKHIQALAKLEAVLAEWIK

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 258 a.a.
• Molecular weight: 28877.26 Da
• Isoelectric Point: 10.0532

>AT259099 WP_012667836.1 NZ_CP104745:c2298736-2297963 [Erwinia pyrifoliae]
MSSKLNWLLQNTAPGSLVLQSWLTKNGISPSLANKYMHSDWLQKLRAGVYVRSGREPQWNDAVLCLQNQLGISVHLAGLT
SLTWQGRSHYLHLTRQAIWLYVEDKASLPKWFKEFPNVEWLLLSNQKLNMNDEKYLTAVEIKGERLKASVPELAAYEIAN
AVPGSLSFEHAAELFQGLVNLSPRKVEVLLQSSRAVKTNRLYLFLADHYAHAWVTRIDKANIDLGAGKRQIVSGGKLDLK
YQITVPASFVSKGISHG

Nucleotide

• Length: 774 bp

Structures

Toxin

• AlphaFold DB: E3DHX2

Antitoxin

• AlphaFold DB: D2T9Q4