Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1570862..1571493 Replicon chromosome
Accession NZ_CP104745
Organism Erwinia pyrifoliae strain CP20113301

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NYP80_RS07650 Protein ID WP_259818053.1
Coordinates 1570862..1571137 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NYP80_RS07655 Protein ID WP_259818054.1
Coordinates 1571134..1571493 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP80_RS07620 (NYP80_07620) 1565986..1566342 + 357 WP_259818045.1 hypothetical protein -
NYP80_RS07625 (NYP80_07625) 1566384..1566935 + 552 WP_259818046.1 hypothetical protein -
NYP80_RS07630 (NYP80_07630) 1567009..1567236 + 228 WP_259818047.1 DUF2732 domain-containing protein -
NYP80_RS07635 (NYP80_07635) 1567236..1567463 + 228 WP_259819510.1 TraR/DksA family transcriptional regulator -
NYP80_RS07640 (NYP80_07640) 1567460..1568266 + 807 WP_259818050.1 DNA adenine methylase -
NYP80_RS07645 (NYP80_07645) 1568482..1570791 + 2310 WP_261648096.1 replication endonuclease -
NYP80_RS07650 (NYP80_07650) 1570862..1571137 + 276 WP_259818053.1 type II toxin-antitoxin system HicA family toxin Toxin
NYP80_RS07655 (NYP80_07655) 1571134..1571493 + 360 WP_259818054.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NYP80_RS07660 (NYP80_07660) 1571773..1571988 + 216 WP_259818056.1 hypothetical protein -
NYP80_RS07665 (NYP80_07665) 1572207..1572800 + 594 WP_259819513.1 hypothetical protein -
NYP80_RS07670 (NYP80_07670) 1572812..1573192 + 381 WP_259819514.1 type II toxin-antitoxin system YafO family toxin -
NYP80_RS07675 (NYP80_07675) 1573646..1574689 - 1044 WP_259819516.1 phage portal protein -
NYP80_RS07680 (NYP80_07680) 1574689..1576416 - 1728 WP_259825666.1 terminase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1560976..1601428 40452


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-86)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10127.67 Da        Isoelectric Point: 10.7783

>T259097 WP_259818053.1 NZ_CP104745:1570862-1571137 [Erwinia pyrifoliae]
MKERVSLLRKKQKSTLEQIFKSPVQSGIRWADVESLIKALGGEVKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVANL
RDWLESTGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13209.89 Da        Isoelectric Point: 4.9001

>AT259097 WP_259818054.1 NZ_CP104745:1571134-1571493 [Erwinia pyrifoliae]
MSKTSTTNTIEIAGQPAVIVFVPELNAFRGKFLGLTGYCDFVSDSIQGLKNEGEISLREYLDDCSAAGIEPYARQEKIKT
FTLRYPESFGERLNQAAAGHETSVNTFIIETLNERMKHA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References