259096

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1127569..1128197 Replicon chromosome
Accession NZ_CP104745
Organism Erwinia pyrifoliae strain CP20113301

Toxin (Protein)


Gene name Hha Uniprot ID D2T444
Locus tag NYP80_RS05370 Protein ID WP_004156337.1
Coordinates 1127569..1127787 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NYP80_RS05375 Protein ID WP_012668861.1
Coordinates 1127817..1128197 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP80_RS05340 (NYP80_05340) 1123553..1123891 + 339 WP_012668866.1 P-II family nitrogen regulator -
NYP80_RS05345 (NYP80_05345) 1123914..1125215 + 1302 WP_012668865.1 ammonium transporter AmtB -
NYP80_RS05350 (NYP80_05350) 1125290..1126150 - 861 WP_012668864.1 acyl-CoA thioesterase II -
NYP80_RS05355 (NYP80_05355) 1126373..1126888 + 516 WP_261648071.1 YbaY family lipoprotein -
NYP80_RS05360 (NYP80_05360) 1126953..1127270 - 318 WP_012668862.1 MGMT family protein -
NYP80_RS05370 (NYP80_05370) 1127569..1127787 - 219 WP_004156337.1 HHA domain-containing protein Toxin
NYP80_RS05375 (NYP80_05375) 1127817..1128197 - 381 WP_012668861.1 Hha toxicity modulator TomB Antitoxin
NYP80_RS05380 (NYP80_05380) 1128344..1128697 - 354 WP_012668860.1 hypothetical protein -
NYP80_RS05385 (NYP80_05385) 1129154..1129300 - 147 WP_012668859.1 type B 50S ribosomal protein L36 -
NYP80_RS05390 (NYP80_05390) 1129311..1129571 - 261 WP_012668858.1 type B 50S ribosomal protein L31 -
NYP80_RS05395 (NYP80_05395) 1129726..1132866 - 3141 WP_012668857.1 multidrug efflux RND transporter permease subunit AcrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8627.06 Da        Isoelectric Point: 8.9007

>T259096 WP_004156337.1 NZ_CP104745:c1127787-1127569 [Erwinia pyrifoliae]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14721.47 Da        Isoelectric Point: 4.8834

>AT259096 WP_012668861.1 NZ_CP104745:c1128197-1127817 [Erwinia pyrifoliae]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDCDLISQIDEYL
DDTFMLFSNYGVNTHDLQRWQKSAKRLFNIFAKECLMSQVQSSHSF

Download         Length: 381 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPQ0

Antitoxin

Source ID Structure

References