Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 473011..474655 Replicon chromosome
Accession NZ_CP104733
Organism Pectobacterium sp. F1-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NAL19_RS02155 Protein ID WP_263058631.1
Coordinates 473321..474655 (+) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NAL19_RS02150 Protein ID WP_225086687.1
Coordinates 473011..473316 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL19_RS02125 (NAL19_462) 468809..469924 + 1116 WP_225086677.1 LPS export ABC transporter permease LptF -
NAL19_RS02130 (NAL19_463) 469924..471000 + 1077 WP_263058629.1 LPS export ABC transporter permease LptG -
NAL19_RS02140 471562..472523 + 962 Protein_412 site-specific integrase -
NAL19_RS02145 (NAL19_466) 472542..472703 + 162 WP_263058630.1 CopG family transcriptional regulator -
NAL19_RS02150 (NAL19_468) 473011..473316 + 306 WP_225086687.1 helix-turn-helix transcriptional regulator Antitoxin
NAL19_RS02155 (NAL19_469) 473321..474655 + 1335 WP_263058631.1 type II toxin-antitoxin system HipA family toxin Toxin
NAL19_RS02160 474871..475679 + 809 WP_263058632.1 IS5 family transposase -
NAL19_RS02165 (NAL19_472) 476272..476904 + 633 WP_225086695.1 LysE family translocator -
NAL19_RS02170 (NAL19_473) 477144..477572 + 429 WP_225086696.1 GNAT family N-acetyltransferase -
NAL19_RS02175 (NAL19_474) 477663..478784 + 1122 WP_263058633.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 439785..477572 37787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 50854.91 Da        Isoelectric Point: 5.8448

>T259083 WP_263058631.1 NZ_CP104733:473321-474655 [Pectobacterium sp. F1-1]
MPRTQQRLAIWMNGIQVGFWEKTRGEDKLQYLPEWIADEQGRPLSLSLLFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
ATRYHADSLEPFDLLAELGRDCVGAIQLLNGNEEPTDLFSVNYRPLCEAEIATILRNTTAALLPGRQDDTDDLRLSIAGA
QEKTALLWHERQWCLPEGSTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLILKEYGIPVAKTQIAQFEEQKALVVERF
DRRWSSDQQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMTILSHSEQAEQDKAQFFRAQIIFWLIAATDGHAKNFS
IAIEPQGRYHLTPLYDVLSAWPVIGPRNNQISWQKCKLAMAVRGSSNYYHLYRIQRRHWVNHGELTGLGRRQVEAMMDDI
ISRTPEVIERVSSLLPESFPPELAECVFDGMRQQCGRLQELHRK

Download         Length: 1335 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11231.01 Da        Isoelectric Point: 10.7356

>AT259083 WP_225086687.1 NZ_CP104733:473011-473316 [Pectobacterium sp. F1-1]
MNTVYPLKTLNQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLEANPGSASIERLFKVLTVLGVEVVLSSGPRVHFSM
SSSTMEEPEKSIGSPARREKW

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References