Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5952458..5953101 Replicon chromosome
Accession NZ_CP104727
Organism Pseudomonas citronellolis strain G5.80

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5P21_RS26105 Protein ID WP_261746786.1
Coordinates 5952688..5953101 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID W5IS21
Locus tag N5P21_RS26100 Protein ID WP_009620639.1
Coordinates 5952458..5952688 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5P21_RS26080 (N5P21_26100) 5948686..5949606 + 921 WP_074976578.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
N5P21_RS26085 (N5P21_26105) 5949603..5950856 + 1254 WP_249917614.1 high-affinity branched-chain amino acid ABC transporter permease LivM -
N5P21_RS26090 (N5P21_26110) 5950853..5951620 + 768 WP_074976582.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
N5P21_RS26095 (N5P21_26115) 5951624..5952325 + 702 WP_009620638.1 ATP-binding cassette domain-containing protein -
N5P21_RS26100 (N5P21_26120) 5952458..5952688 + 231 WP_009620639.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
N5P21_RS26105 (N5P21_26125) 5952688..5953101 + 414 WP_261746786.1 tRNA(fMet)-specific endonuclease VapC Toxin
N5P21_RS26110 (N5P21_26130) 5953558..5954247 - 690 WP_249917615.1 GntR family transcriptional regulator -
N5P21_RS26115 (N5P21_26135) 5954312..5955046 - 735 WP_009620642.1 SDR family oxidoreductase -
N5P21_RS26120 (N5P21_26140) 5955199..5956263 + 1065 WP_061560909.1 phosphotransferase -
N5P21_RS26125 (N5P21_26145) 5956260..5957582 + 1323 WP_256514598.1 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
N5P21_RS26130 (N5P21_26150) 5957596..5958054 - 459 WP_064582221.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15223.57 Da        Isoelectric Point: 6.9789

>T259074 WP_261746786.1 NZ_CP104727:5952688-5953101 [Pseudomonas citronellolis]
MLKFMLDTNICIFTIKNKPQVVREAFNQHHGQLAISSVTLMELIYGAEKSSMPEHNLGIIEGFAARLEVLDYDGNAAAHT
GQLRAELARIGKPIGPYDQMIAGHARSRGLILVSNNLREFERVPGLRLEDWTIAPSP

Download         Length: 414 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.43 Da        Isoelectric Point: 4.3094

>AT259074 WP_009620639.1 NZ_CP104727:5952458-5952688 [Pseudomonas citronellolis]
MEQGAVFQSNRSQAVRLPKAVALPEDVKRVDVVAIGRTRILTPAGESWDSWFDGENVSADFMSEREQPAEQEREGF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5DDH0

References