259068

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1448509..1449086 Replicon chromosome
Accession NZ_CP104727
Organism Pseudomonas citronellolis strain G5.80

Toxin (Protein)


Gene name hicA Uniprot ID A0A4Z0IIZ1
Locus tag N5P21_RS06450 Protein ID WP_074984997.1
Coordinates 1448832..1449086 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4Z0ILE6
Locus tag N5P21_RS06445 Protein ID WP_074984995.1
Coordinates 1448509..1448835 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5P21_RS06425 (N5P21_06425) 1444386..1445567 + 1182 WP_024128460.1 two-component system response regulator -
N5P21_RS06430 (N5P21_06430) 1445660..1446553 + 894 WP_074984989.1 PA4780 family RIO1-like protein kinase -
N5P21_RS06435 (N5P21_06435) 1446550..1447101 + 552 WP_249920208.1 nucleotidyltransferase family protein -
N5P21_RS06440 (N5P21_06440) 1447191..1448081 + 891 WP_261747741.1 EamA family transporter -
N5P21_RS06445 (N5P21_06445) 1448509..1448835 - 327 WP_074984995.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N5P21_RS06450 (N5P21_06450) 1448832..1449086 - 255 WP_074984997.1 type II toxin-antitoxin system HicA family toxin Toxin
N5P21_RS06455 (N5P21_06455) 1449341..1449742 - 402 WP_253392247.1 Cu(I)-responsive transcriptional regulator -
N5P21_RS06460 (N5P21_06460) 1449729..1452152 - 2424 WP_253411558.1 heavy metal translocating P-type ATPase -
N5P21_RS06465 (N5P21_06465) 1452262..1452666 - 405 WP_253392249.1 hypothetical protein -
N5P21_RS06470 (N5P21_06470) 1452819..1453016 + 198 WP_009616013.1 cation transporter -
N5P21_RS06475 (N5P21_06475) 1452995..1453648 - 654 WP_116425555.1 TetR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-73)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9419.81 Da        Isoelectric Point: 10.1609

>T259068 WP_074984997.1 NZ_CP104727:c1449086-1448832 [Pseudomonas citronellolis]
MNSRQRATLEALYAVPTPCNLEWARIESLLLSLGARLIEGNGSRVRFELNGVIASFHRPHPAKEAKPYQVRDARAFIERA
GYAP

Download         Length: 255 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12075.71 Da        Isoelectric Point: 6.0781

>AT259068 WP_074984995.1 NZ_CP104727:c1448835-1448509 [Pseudomonas citronellolis]
MSPMKYKGYVARIEYSDDDGLFIGHIAGIQDVIGFHGESVSELRQLFHEAVDDYLDTCAKLGREPQKPYSGKLSLRLDPA
LHARVALKAELSNKSINQWVAERLSEAV

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z0IIZ1

Antitoxin

Source ID Structure
AlphaFold DB A0A4Z0ILE6

References