Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1076306..1076926 Replicon chromosome
Accession NZ_CP104724
Organism Enterobacter kobei strain SG.H2a

Toxin (Protein)


Gene name Hha Uniprot ID A0A2W0G488
Locus tag N5P26_RS05055 Protein ID WP_014882802.1
Coordinates 1076306..1076524 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag N5P26_RS05060 Protein ID WP_008499288.1
Coordinates 1076552..1076926 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5P26_RS05025 (N5P26_05025) 1072315..1072575 + 261 WP_261660346.1 type B 50S ribosomal protein L31 -
N5P26_RS05030 (N5P26_05030) 1072578..1072718 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
N5P26_RS05035 (N5P26_05035) 1072715..1073425 - 711 WP_069601783.1 GNAT family protein -
N5P26_RS05040 (N5P26_05040) 1073527..1074987 + 1461 WP_014882799.1 PLP-dependent aminotransferase family protein -
N5P26_RS05045 (N5P26_05045) 1074959..1075426 - 468 WP_014882800.1 YlaC family protein -
N5P26_RS05050 (N5P26_05050) 1075545..1076096 - 552 WP_014882801.1 maltose O-acetyltransferase -
N5P26_RS05055 (N5P26_05055) 1076306..1076524 - 219 WP_014882802.1 HHA domain-containing protein Toxin
N5P26_RS05060 (N5P26_05060) 1076552..1076926 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
N5P26_RS05065 (N5P26_05065) 1077438..1080584 - 3147 WP_014882803.1 multidrug efflux RND transporter permease subunit AcrB -
N5P26_RS05070 (N5P26_05070) 1080607..1081800 - 1194 WP_014882804.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T259057 WP_014882802.1 NZ_CP104724:c1076524-1076306 [Enterobacter kobei]
MSEKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT259057 WP_008499288.1 NZ_CP104724:c1076926-1076552 [Enterobacter kobei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G488

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References