Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4246104..4246699 Replicon chromosome
Accession NZ_CP104721
Organism Escherichia coli strain ECO3183

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag N5O92_RS20400 Protein ID WP_000239579.1
Coordinates 4246104..4246454 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag N5O92_RS20405 Protein ID WP_001223208.1
Coordinates 4246448..4246699 (-) Length 84 a.a.

Genomic Context

N5O92_RS20395N5O92_RS20380N5O92_RS20385N5O92_RS20390N5O92_RS20400N5O92_RS20405N5O92_RS20410N5O92_RS20415
Location: 4245494..4246024 (531 bp)
Type: Others
Protein ID: WP_000055072.1
Location: 4241551..4242575 (1025 bp)
Type: Others
Protein ID: Protein_3986
Location: 4242586..4244088 (1503 bp)
Type: Others
Protein ID: WP_000205784.1
Location: 4244228..4245184 (957 bp)
Type: Others
Protein ID: WP_000265933.1
Location: 4246104..4246454 (351 bp)
Type: Toxin
Protein ID: WP_000239579.1
Location: 4246448..4246699 (252 bp)
Type: Antitoxin
Protein ID: WP_001223208.1
Location: 4246911..4247252 (342 bp)
Type: Others
Protein ID: WP_001219160.1
Location: 4247255..4251034 (3780 bp)
Type: Others
Protein ID: WP_000060978.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N5O92_RS20380 (4241551)4241551..4242575-1025Protein_3986ABC transporter permease-
N5O92_RS20385 (4242586)4242586..4244088-1503WP_000205784.1sugar ABC transporter ATP-binding protein-
N5O92_RS20390 (4244228)4244228..4245184-957WP_000265933.1galactofuranose ABC transporter substrate-binding protein YtfQ-
N5O92_RS20395 (4245494)4245494..4246024+531WP_000055072.1inorganic diphosphatase-
N5O92_RS20400 (4246104)4246104..4246454-351WP_000239579.1endoribonuclease toxin ChpBToxin
N5O92_RS20405 (4246448)4246448..4246699-252WP_001223208.1type II toxin-antitoxin system antitoxin ChpSAntitoxin
N5O92_RS20410 (4246911)4246911..4247252-342WP_001219160.1gamma-glutamylcyclotransferase-
N5O92_RS20415 (4247255)4247255..4251034-3780WP_000060978.1autotransporter assembly complex protein TamB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T259052 WP_000239579.1 NZ_CP104721:c4246454-4246104 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT259052 WP_001223208.1 NZ_CP104721:c4246699-4246448 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E0Y8A8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U9LQ26

References