Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4246104..4246699 Replicon chromosome
Accession NZ_CP104721
Organism Escherichia coli strain ECO3183

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag N5O92_RS20400 Protein ID WP_000239579.1
Coordinates 4246104..4246454 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag N5O92_RS20405 Protein ID WP_001223208.1
Coordinates 4246448..4246699 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O92_RS20380 (4241551) 4241551..4242575 - 1025 Protein_3986 ABC transporter permease -
N5O92_RS20385 (4242586) 4242586..4244088 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
N5O92_RS20390 (4244228) 4244228..4245184 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N5O92_RS20395 (4245494) 4245494..4246024 + 531 WP_000055072.1 inorganic diphosphatase -
N5O92_RS20400 (4246104) 4246104..4246454 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
N5O92_RS20405 (4246448) 4246448..4246699 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N5O92_RS20410 (4246911) 4246911..4247252 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N5O92_RS20415 (4247255) 4247255..4251034 - 3780 WP_000060978.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T259052 WP_000239579.1 NZ_CP104721:c4246454-4246104 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT259052 WP_001223208.1 NZ_CP104721:c4246699-4246448 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References