Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4199947..4201204 Replicon chromosome
Accession NZ_CP104720
Organism Pseudomonas aeruginosa strain NY4593

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag N5P33_RS19560 Protein ID WP_023084953.1
Coordinates 4199947..4200702 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag N5P33_RS19565 Protein ID WP_003086329.1
Coordinates 4200836..4201204 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5P33_RS19550 (N5P33_19550) 4195120..4197663 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
N5P33_RS19555 (N5P33_19555) 4197818..4199179 - 1362 WP_003081943.1 DNA recombination protein RmuC -
N5P33_RS19560 (N5P33_19560) 4199947..4200702 - 756 WP_023084953.1 RES family NAD+ phosphorylase Toxin
N5P33_RS19565 (N5P33_19565) 4200836..4201204 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
N5P33_RS19570 (N5P33_19570) 4201277..4202563 - 1287 WP_034071738.1 FAD-binding oxidoreductase -
N5P33_RS19575 (N5P33_19575) 4202619..4204208 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
N5P33_RS19580 (N5P33_19580) 4204287..4204763 + 477 WP_003140638.1 hypothetical protein -
N5P33_RS19585 (N5P33_19585) 4204766..4205041 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28310.49 Da        Isoelectric Point: 7.7294

>T259032 WP_023084953.1 NZ_CP104720:c4200702-4199947 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259032 WP_003086329.1 NZ_CP104720:c4201204-4200836 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References