Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3253835..3255056 Replicon chromosome
Accession NZ_CP104720
Organism Pseudomonas aeruginosa strain NY4593

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5P33_RS15110 Protein ID WP_003114949.1
Coordinates 3254478..3255056 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N5P33_RS15105 Protein ID WP_003088112.1
Coordinates 3253835..3254389 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5P33_RS15080 (N5P33_15080) 3249403..3249954 + 552 WP_016253541.1 helix-turn-helix domain-containing protein -
N5P33_RS15085 (N5P33_15085) 3249951..3250349 - 399 WP_003117664.1 NADH-quinone oxidoreductase subunit A -
N5P33_RS15090 (N5P33_15090) 3250362..3250685 - 324 WP_003102734.1 multidrug efflux SMR transporter -
N5P33_RS15095 (N5P33_15095) 3251016..3251477 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
N5P33_RS15100 (N5P33_15100) 3251482..3253677 + 2196 WP_016561792.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
N5P33_RS15105 (N5P33_15105) 3253835..3254389 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
N5P33_RS15110 (N5P33_15110) 3254478..3255056 + 579 WP_003114949.1 HD domain-containing protein Toxin
N5P33_RS15115 (N5P33_15115) 3255165..3256352 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
N5P33_RS15120 (N5P33_15120) 3256342..3258513 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
N5P33_RS15125 (N5P33_15125) 3258503..3258808 - 306 WP_229035508.1 TolC family protein -
N5P33_RS15130 (N5P33_15130) 3259208..3259623 - 416 Protein_2991 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T259031 WP_003114949.1 NZ_CP104720:3254478-3255056 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT259031 WP_003088112.1 NZ_CP104720:3253835-3254389 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References