Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 144178..144683 Replicon chromosome
Accession NZ_CP104720
Organism Pseudomonas aeruginosa strain NY4593

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag N5P33_RS00660 Protein ID WP_003083773.1
Coordinates 144178..144459 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag N5P33_RS00665 Protein ID WP_003112628.1
Coordinates 144456..144683 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5P33_RS00635 (N5P33_00635) 139429..140778 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
N5P33_RS00640 (N5P33_00640) 140827..141513 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
N5P33_RS00645 (N5P33_00645) 141614..142348 + 735 WP_003117208.1 GntR family transcriptional regulator -
N5P33_RS00650 (N5P33_00650) 142528..142938 + 411 WP_003101225.1 aegerolysin family protein -
N5P33_RS00655 (N5P33_00655) 142970..143878 - 909 WP_003083769.1 LysR family transcriptional regulator -
N5P33_RS00660 (N5P33_00660) 144178..144459 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
N5P33_RS00665 (N5P33_00665) 144456..144683 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
N5P33_RS00670 (N5P33_00670) 144859..145479 - 621 WP_003101226.1 hypothetical protein -
N5P33_RS00675 (N5P33_00675) 145580..146080 + 501 WP_003112629.1 LEA type 2 family protein -
N5P33_RS00680 (N5P33_00680) 146153..146494 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
N5P33_RS00685 (N5P33_00685) 146576..148003 - 1428 WP_003083784.1 GABA permease -
N5P33_RS00690 (N5P33_00690) 148172..149665 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T259029 WP_003083773.1 NZ_CP104720:c144459-144178 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT259029 WP_003112628.1 NZ_CP104720:c144683-144456 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References