Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3735474..3737045 Replicon chromosome
Accession NZ_CP104698
Organism Proteus mirabilis strain NG-ABK-32

Toxin (Protein)


Gene name hipA Uniprot ID B4F0T8
Locus tag N6W67_RS17755 Protein ID WP_012368637.1
Coordinates 3735732..3737045 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag N6W67_RS17750 Protein ID WP_004249771.1
Coordinates 3735474..3735731 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6W67_RS17725 (N6W67_17725) 3731436..3731579 + 144 WP_004246509.1 50S ribosomal protein L34 -
N6W67_RS17730 (N6W67_17730) 3731597..3731956 + 360 WP_004246510.1 ribonuclease P protein component -
N6W67_RS17735 (N6W67_17735) 3731920..3732180 + 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
N6W67_RS17740 (N6W67_17740) 3732183..3733823 + 1641 WP_004246512.1 membrane protein insertase YidC -
N6W67_RS17745 (N6W67_17745) 3733961..3735325 + 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
N6W67_RS17750 (N6W67_17750) 3735474..3735731 + 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
N6W67_RS17755 (N6W67_17755) 3735732..3737045 + 1314 WP_012368637.1 type II toxin-antitoxin system HipA family toxin Toxin
N6W67_RS17760 (N6W67_17760) 3737447..3737911 + 465 WP_004249773.1 DUF1097 domain-containing protein -
N6W67_RS17765 (N6W67_17765) 3738096..3739025 + 930 WP_004246518.1 metallophosphoesterase -
N6W67_RS17770 (N6W67_17770) 3739057..3741018 + 1962 WP_261625287.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
N6W67_RS17775 (N6W67_17775) 3741072..3741875 - 804 WP_049201519.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49670.78 Da        Isoelectric Point: 6.5023

>T259028 WP_012368637.1 NZ_CP104698:3735732-3737045 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT259028 WP_004249771.1 NZ_CP104698:3735474-3735731 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4F0T8

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References