Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3289509..3290158 Replicon chromosome
Accession NZ_CP104698
Organism Proteus mirabilis strain NG-ABK-32

Toxin (Protein)


Gene name vagD Uniprot ID B4EZB9
Locus tag N6W67_RS15670 Protein ID WP_012368534.1
Coordinates 3289509..3289928 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B4EZC0
Locus tag N6W67_RS15675 Protein ID WP_012368535.1
Coordinates 3289925..3290158 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6W67_RS15640 (N6W67_15640) 3284786..3285664 - 879 WP_049203255.1 23S rRNA pseudouridine(2604) synthase RluF -
N6W67_RS15645 (N6W67_15645) 3285840..3286754 - 915 WP_004249085.1 fatty acid biosynthesis protein FabY -
N6W67_RS15650 (N6W67_15650) 3286778..3287215 - 438 WP_004246810.1 D-aminoacyl-tRNA deacylase -
N6W67_RS15655 (N6W67_15655) 3287296..3287913 - 618 WP_004246809.1 glucose-1-phosphatase -
N6W67_RS15660 (N6W67_15660) 3288567..3288983 - 417 WP_049208252.1 hypothetical protein -
N6W67_RS15665 (N6W67_15665) 3288961..3289284 - 324 WP_049208253.1 hypothetical protein -
N6W67_RS15670 (N6W67_15670) 3289509..3289928 - 420 WP_012368534.1 type II toxin-antitoxin system VapC family toxin Toxin
N6W67_RS15675 (N6W67_15675) 3289925..3290158 - 234 WP_012368535.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N6W67_RS15680 (N6W67_15680) 3290909..3292744 - 1836 WP_004246802.1 ribosome-dependent GTPase TypA -
N6W67_RS15685 (N6W67_15685) 3293104..3294513 + 1410 WP_004246801.1 glutamate--ammonia ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15371.88 Da        Isoelectric Point: 7.7288

>T259026 WP_012368534.1 NZ_CP104698:c3289928-3289509 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Download         Length: 420 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8890.06 Da        Isoelectric Point: 4.4870

>AT259026 WP_012368535.1 NZ_CP104698:c3290158-3289925 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZB9

Antitoxin

Source ID Structure
AlphaFold DB B4EZC0

References