259025

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3268940..3269639 Replicon chromosome
Accession NZ_CP104698
Organism Proteus mirabilis strain NG-ABK-32

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N6W67_RS15565 Protein ID WP_261625273.1
Coordinates 3268940..3269326 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag N6W67_RS15570 Protein ID WP_004246828.1
Coordinates 3269319..3269639 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6W67_RS15550 (N6W67_15550) 3264959..3265540 - 582 WP_004246833.1 DNA-3-methyladenine glycosylase I -
N6W67_RS15555 (N6W67_15555) 3265791..3266696 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
N6W67_RS15560 (N6W67_15560) 3266706..3268778 + 2073 WP_017827114.1 glycine--tRNA ligase subunit beta -
N6W67_RS15565 (N6W67_15565) 3268940..3269326 + 387 WP_261625273.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N6W67_RS15570 (N6W67_15570) 3269319..3269639 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
N6W67_RS15575 (N6W67_15575) 3269688..3270122 - 435 WP_004246827.1 hypothetical protein -
N6W67_RS15580 (N6W67_15580) 3270115..3270999 - 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
N6W67_RS15585 (N6W67_15585) 3271213..3272499 - 1287 WP_004249090.1 DUF3748 domain-containing protein -
N6W67_RS15590 (N6W67_15590) 3272636..3273253 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
N6W67_RS15595 (N6W67_15595) 3273555..3274178 + 624 WP_004246821.1 guanylate kinase -
N6W67_RS15600 (N6W67_15600) 3274233..3274508 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14342.73 Da        Isoelectric Point: 10.1203

>T259025 WP_261625273.1 NZ_CP104698:3268940-3269326 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFAYGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT259025 WP_004246828.1 NZ_CP104698:3269319-3269639 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References