Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 137656..138182 Replicon plasmid unnamed1
Accession NZ_CP104692
Organism Enterobacter hormaechei strain 2022CK-00453

Toxin (Protein)


Gene name relE Uniprot ID A0A7R6HXL1
Locus tag N5934_RS23295 Protein ID WP_015572079.1
Coordinates 137895..138182 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag N5934_RS23290 Protein ID WP_000534858.1
Coordinates 137656..137895 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5934_RS23260 (N5934_23260) 132728..133664 - 937 Protein_151 GlxA family transcriptional regulator -
N5934_RS23265 (N5934_23265) 133675..134877 - 1203 WP_015572077.1 MFS transporter -
N5934_RS23270 (N5934_23270) 134917..135678 - 762 WP_004118132.1 SDR family NAD(P)-dependent oxidoreductase -
N5934_RS23275 (N5934_23275) 135708..136523 - 816 WP_032670836.1 SDR family oxidoreductase -
N5934_RS23280 (N5934_23280) 136987..137307 + 321 WP_004197483.1 hypothetical protein -
N5934_RS23285 (N5934_23285) 137529..137631 - 103 Protein_156 hypothetical protein -
N5934_RS23290 (N5934_23290) 137656..137895 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
N5934_RS23295 (N5934_23295) 137895..138182 + 288 WP_015572079.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5934_RS23300 (N5934_23300) 138254..138412 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
N5934_RS23305 (N5934_23305) 139281..139574 + 294 WP_032670838.1 hypothetical protein -
N5934_RS23310 (N5934_23310) 139591..140412 + 822 WP_015572081.1 DUF932 domain-containing protein -
N5934_RS23315 (N5934_23315) 140441..140980 - 540 WP_032664846.1 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..143089 143089
- flank IS/Tn - - 141365..143071 1706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11209.09 Da        Isoelectric Point: 10.0714

>T259023 WP_015572079.1 NZ_CP104692:137895-138182 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKNKLAEVLESPRIDANKLRGMHDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT259023 WP_000534858.1 NZ_CP104692:137656-137895 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References