Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4557952..4558691 Replicon chromosome
Accession NZ_CP104691
Organism Enterobacter hormaechei strain 2022CK-00453

Toxin (Protein)


Gene name tacT Uniprot ID A0A801DRD7
Locus tag N5934_RS21985 Protein ID WP_017693417.1
Coordinates 4558206..4558691 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag N5934_RS21980 Protein ID WP_003857131.1
Coordinates 4557952..4558218 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5934_RS21960 (N5934_21960) 4553434..4554420 + 987 WP_023296632.1 DUF979 domain-containing protein -
N5934_RS21965 (N5934_21965) 4554430..4555425 + 996 WP_015570513.1 DUF2891 domain-containing protein -
N5934_RS21970 (N5934_21970) 4555447..4556829 - 1383 WP_110870590.1 MFS transporter -
N5934_RS21975 (N5934_21975) 4556959..4557888 + 930 WP_110870592.1 LysR family transcriptional regulator -
N5934_RS21980 (N5934_21980) 4557952..4558218 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
N5934_RS21985 (N5934_21985) 4558206..4558691 + 486 WP_017693417.1 GNAT family N-acetyltransferase Toxin
N5934_RS21990 (N5934_21990) 4558869..4560161 - 1293 WP_110870594.1 glycosyl hydrolase family 28 protein -
N5934_RS21995 (N5934_21995) 4560266..4561024 - 759 WP_047637345.1 DeoR/GlpR family DNA-binding transcription regulator -
N5934_RS22000 (N5934_22000) 4561111..4561695 + 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
N5934_RS22005 (N5934_22005) 4561780..4562538 + 759 WP_063151482.1 trans-aconitate 2-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17570.26 Da        Isoelectric Point: 9.9658

>T259021 WP_017693417.1 NZ_CP104691:4558206-4558691 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKTFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT259021 WP_003857131.1 NZ_CP104691:4557952-4558218 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References