Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1922525..1923138 Replicon chromosome
Accession NC_016804
Organism Mycobacterium bovis BCG str. Mexico

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag BCGMEX_RS08920 Protein ID WP_003408465.1
Coordinates 1922525..1922914 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag BCGMEX_RS08925 Protein ID WP_003408469.1
Coordinates 1922911..1923138 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGMEX_RS08885 1918155..1919069 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
BCGMEX_RS08890 1919072..1919902 + 831 WP_003408448.1 cyclase family protein -
BCGMEX_RS08895 1919902..1920252 + 351 WP_003898986.1 cupin domain-containing protein -
BCGMEX_RS08900 1920305..1921122 + 818 Protein_1737 3-keto-5-aminohexanoate cleavage protein -
BCGMEX_RS08905 1921136..1921915 + 780 WP_003408460.1 IclR family transcriptional regulator -
BCGMEX_RS08920 1922525..1922914 - 390 WP_003408465.1 PIN domain-containing protein Toxin
BCGMEX_RS08925 1922911..1923138 - 228 WP_003408469.1 antitoxin Antitoxin
BCGMEX_RS08930 1923356..1924840 + 1485 WP_010950580.1 biotin carboxylase -
BCGMEX_RS08935 1924837..1926084 + 1248 WP_003408476.1 serine hydrolase -
BCGMEX_RS08940 1926127..1926546 - 420 WP_003408483.1 hypothetical protein -
BCGMEX_RS08945 1926536..1927246 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T25902 WP_003408465.1 NC_016804:c1922914-1922525 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T25902 NC_016804:c1922914-1922525 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT25902 WP_003408469.1 NC_016804:c1923138-1922911 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT25902 NC_016804:c1923138-1922911 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References