Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3181027..3181684 Replicon chromosome
Accession NZ_CP104691
Organism Enterobacter hormaechei strain 2022CK-00453

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T9SH06
Locus tag N5934_RS15520 Protein ID WP_023295382.1
Coordinates 3181274..3181684 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag N5934_RS15515 Protein ID WP_003863437.1
Coordinates 3181027..3181293 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5934_RS15495 (N5934_15495) 3176433..3177866 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
N5934_RS15500 (N5934_15500) 3177986..3178714 - 729 WP_039269836.1 MurR/RpiR family transcriptional regulator -
N5934_RS15505 (N5934_15505) 3178981..3179640 + 660 WP_003863433.1 hemolysin III family protein -
N5934_RS15510 (N5934_15510) 3179752..3180732 - 981 WP_039269839.1 tRNA-modifying protein YgfZ -
N5934_RS15515 (N5934_15515) 3181027..3181293 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
N5934_RS15520 (N5934_15520) 3181274..3181684 + 411 WP_023295382.1 protein YgfX Toxin
N5934_RS15525 (N5934_15525) 3181686..3182207 - 522 WP_015571793.1 flavodoxin FldB -
N5934_RS15530 (N5934_15530) 3182309..3183205 + 897 WP_261655898.1 site-specific tyrosine recombinase XerD -
N5934_RS15535 (N5934_15535) 3183234..3183947 + 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5934_RS15540 (N5934_15540) 3183953..3185686 + 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16291.18 Da        Isoelectric Point: 11.4775

>T259016 WP_023295382.1 NZ_CP104691:3181274-3181684 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGAPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT259016 WP_003863437.1 NZ_CP104691:3181027-3181293 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9SH06

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References