Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2338023..2338639 Replicon chromosome
Accession NZ_CP104691
Organism Enterobacter hormaechei strain 2022CK-00453

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5934_RS11465 Protein ID WP_077266491.1
Coordinates 2338268..2338639 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag N5934_RS11460 Protein ID WP_015569912.1
Coordinates 2338023..2338265 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5934_RS11430 (N5934_11430) 2333082..2333882 + 801 WP_261656890.1 DeoR/GlpR family DNA-binding transcription regulator -
N5934_RS11435 (N5934_11435) 2334001..2334600 + 600 WP_017694048.1 glucose-1-phosphatase -
N5934_RS11440 (N5934_11440) 2334594..2335475 + 882 WP_003861949.1 virulence factor BrkB family protein -
N5934_RS11445 (N5934_11445) 2335472..2335909 + 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
N5934_RS11450 (N5934_11450) 2335954..2336895 + 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
N5934_RS11455 (N5934_11455) 2336904..2337824 - 921 WP_017382675.1 alpha/beta hydrolase -
N5934_RS11460 (N5934_11460) 2338023..2338265 + 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
N5934_RS11465 (N5934_11465) 2338268..2338639 + 372 WP_077266491.1 type II toxin-antitoxin system VapC family toxin Toxin
N5934_RS11470 (N5934_11470) 2338679..2339608 - 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
N5934_RS11475 (N5934_11475) 2339605..2340240 - 636 WP_003861958.1 formate dehydrogenase cytochrome b556 subunit -
N5934_RS11480 (N5934_11480) 2340237..2341139 - 903 WP_014072386.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13723.85 Da        Isoelectric Point: 6.4882

>T259015 WP_077266491.1 NZ_CP104691:2338268-2338639 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9408.66 Da        Isoelectric Point: 4.4076

>AT259015 WP_015569912.1 NZ_CP104691:2338023-2338265 [Enterobacter hormaechei]
VSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References