Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1608480..1609056 Replicon chromosome
Accession NZ_CP104691
Organism Enterobacter hormaechei strain 2022CK-00453

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag N5934_RS07965 Protein ID WP_015572580.1
Coordinates 1608769..1609056 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag N5934_RS07960 Protein ID WP_017694570.1
Coordinates 1608480..1608782 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5934_RS07940 (N5934_07940) 1604776..1605321 + 546 WP_006810254.1 YfaZ family outer membrane protein -
N5934_RS07945 (N5934_07945) 1605498..1606868 - 1371 WP_110871120.1 NAD-dependent succinate-semialdehyde dehydrogenase -
N5934_RS07950 (N5934_07950) 1607022..1607774 + 753 WP_033486709.1 AraC family transcriptional regulator -
N5934_RS07955 (N5934_07955) 1607813..1608451 + 639 WP_110871122.1 LysE family translocator -
N5934_RS07960 (N5934_07960) 1608480..1608782 - 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
N5934_RS07965 (N5934_07965) 1608769..1609056 - 288 WP_015572580.1 BrnT family toxin Toxin
N5934_RS07970 (N5934_07970) 1609226..1610497 + 1272 WP_110871124.1 DUF445 domain-containing protein -
N5934_RS07975 (N5934_07975) 1610494..1611570 - 1077 WP_015572578.1 DUF2955 domain-containing protein -
N5934_RS07980 (N5934_07980) 1611560..1612627 - 1068 WP_108394134.1 HlyD family secretion protein -
N5934_RS07985 (N5934_07985) 1612624..1613094 - 471 WP_023295868.1 MarR family transcriptional regulator -
N5934_RS07990 (N5934_07990) 1613244..1613963 - 720 WP_045330246.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T259014 WP_015572580.1 NZ_CP104691:c1609056-1608769 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT259014 WP_017694570.1 NZ_CP104691:c1608782-1608480 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References