Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1138656..1139276 Replicon chromosome
Accession NZ_CP104691
Organism Enterobacter hormaechei strain 2022CK-00453

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag N5934_RS05780 Protein ID WP_015571250.1
Coordinates 1139058..1139276 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag N5934_RS05775 Protein ID WP_006809850.1
Coordinates 1138656..1139030 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5934_RS05765 (N5934_05765) 1133783..1134976 + 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5934_RS05770 (N5934_05770) 1134999..1138145 + 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
N5934_RS05775 (N5934_05775) 1138656..1139030 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
N5934_RS05780 (N5934_05780) 1139058..1139276 + 219 WP_015571250.1 HHA domain-containing protein Toxin
N5934_RS05785 (N5934_05785) 1139485..1140036 + 552 WP_110870982.1 maltose O-acetyltransferase -
N5934_RS05790 (N5934_05790) 1140153..1140620 + 468 WP_023296041.1 YlaC family protein -
N5934_RS05795 (N5934_05795) 1140592..1142052 - 1461 WP_261656130.1 PLP-dependent aminotransferase family protein -
N5934_RS05800 (N5934_05800) 1142154..1142864 + 711 WP_110870984.1 GNAT family protein -
N5934_RS05805 (N5934_05805) 1142861..1143001 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
N5934_RS05810 (N5934_05810) 1143004..1143264 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T259013 WP_015571250.1 NZ_CP104691:1139058-1139276 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT259013 WP_006809850.1 NZ_CP104691:1138656-1139030 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References