Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 538232..539029 Replicon chromosome
Accession NZ_CP104691
Organism Enterobacter hormaechei strain 2022CK-00453

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag N5934_RS02985 Protein ID WP_110870847.1
Coordinates 538232..538753 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A331QJY7
Locus tag N5934_RS02990 Protein ID WP_015570876.1
Coordinates 538760..539029 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5934_RS02955 (N5934_02955) 533830..534519 + 690 WP_045349209.1 pyrimidine utilization protein B -
N5934_RS02960 (N5934_02960) 534531..534917 + 387 WP_015570870.1 pyrimidine utilization protein C -
N5934_RS02965 (N5934_02965) 534925..535725 + 801 WP_110870841.1 pyrimidine utilization protein D -
N5934_RS02970 (N5934_02970) 535735..536325 + 591 WP_110870843.1 malonic semialdehyde reductase -
N5934_RS02975 (N5934_02975) 536338..536829 + 492 WP_110870845.1 pyrimidine utilization flavin reductase protein F -
N5934_RS02980 (N5934_02980) 536851..538173 + 1323 WP_047717623.1 pyrimidine utilization transport protein G -
N5934_RS02985 (N5934_02985) 538232..538753 - 522 WP_110870847.1 GNAT family N-acetyltransferase Toxin
N5934_RS02990 (N5934_02990) 538760..539029 - 270 WP_015570876.1 DUF1778 domain-containing protein Antitoxin
N5934_RS02995 (N5934_02995) 539103..540008 - 906 WP_032653183.1 DMT family transporter -
N5934_RS03000 (N5934_03000) 540125..540295 - 171 WP_001273664.1 general stress protein -
N5934_RS03005 (N5934_03005) 540687..541283 + 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
N5934_RS03010 (N5934_03010) 541302..541529 + 228 WP_006809324.1 YccJ family protein -
N5934_RS03015 (N5934_03015) 541562..542803 - 1242 WP_047729185.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
N5934_RS03020 (N5934_03020) 542956..543051 + 96 Protein_598 transcriptional regulator -
N5934_RS03025 (N5934_03025) 543130..543489 - 360 WP_017384779.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19463.27 Da        Isoelectric Point: 7.4318

>T259012 WP_110870847.1 NZ_CP104691:c538753-538232 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKIQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10247.75 Da        Isoelectric Point: 5.8836

>AT259012 WP_015570876.1 NZ_CP104691:c539029-538760 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A331QJY7

References