Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4545181..4545797 Replicon chromosome
Accession NZ_CP104689
Organism Enterobacter hormaechei strain 2020CK-00376

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N5929_RS21670 Protein ID WP_045327153.1
Coordinates 4545181..4545552 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag N5929_RS21675 Protein ID WP_015569912.1
Coordinates 4545555..4545797 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5929_RS21655 (N5929_14185) 4542681..4543583 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
N5929_RS21660 (N5929_14180) 4543580..4544215 + 636 WP_003861958.1 formate dehydrogenase cytochrome b556 subunit -
N5929_RS21665 (N5929_14175) 4544212..4545141 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
N5929_RS21670 (N5929_14170) 4545181..4545552 - 372 WP_045327153.1 type II toxin-antitoxin system VapC family toxin Toxin
N5929_RS21675 (N5929_14165) 4545555..4545797 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
N5929_RS21680 (N5929_14160) 4545996..4546916 + 921 WP_023295638.1 alpha/beta hydrolase -
N5929_RS21685 (N5929_14155) 4546925..4547866 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
N5929_RS21690 (N5929_14150) 4547911..4548348 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
N5929_RS21695 (N5929_14145) 4548345..4549226 - 882 WP_003861949.1 virulence factor BrkB family protein -
N5929_RS21700 (N5929_14140) 4549220..4549819 - 600 WP_003861947.1 glucose-1-phosphatase -
N5929_RS21705 (N5929_14135) 4549938..4550738 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13697.77 Da        Isoelectric Point: 6.4882

>T259011 WP_045327153.1 NZ_CP104689:c4545552-4545181 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVSLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT259011 WP_015569912.1 NZ_CP104689:c4545797-4545555 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References