Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3655281..3655938 Replicon chromosome
Accession NZ_CP104689
Organism Enterobacter hormaechei strain 2020CK-00376

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag N5929_RS17400 Protein ID WP_017382887.1
Coordinates 3655281..3655691 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag N5929_RS17405 Protein ID WP_003863437.1
Coordinates 3655672..3655938 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5929_RS17380 (N5929_18485) 3651279..3653012 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
N5929_RS17385 (N5929_18480) 3653018..3653731 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5929_RS17390 (N5929_18475) 3653760..3654656 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
N5929_RS17395 (N5929_18470) 3654758..3655279 + 522 WP_015571793.1 flavodoxin FldB -
N5929_RS17400 (N5929_18465) 3655281..3655691 - 411 WP_017382887.1 protein YgfX Toxin
N5929_RS17405 (N5929_18460) 3655672..3655938 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
N5929_RS17410 (N5929_18455) 3656233..3657213 + 981 WP_261666021.1 tRNA-modifying protein YgfZ -
N5929_RS17415 (N5929_18450) 3657325..3657984 - 660 WP_003863433.1 hemolysin III family protein -
N5929_RS17420 (N5929_18445) 3658251..3658982 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
N5929_RS17425 (N5929_18440) 3659099..3660532 + 1434 WP_023295383.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T259010 WP_017382887.1 NZ_CP104689:c3655691-3655281 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT259010 WP_003863437.1 NZ_CP104689:c3655938-3655672 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References