Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 621070..621646 Replicon chromosome
Accession NZ_CP104689
Organism Enterobacter hormaechei strain 2020CK-00376

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag N5929_RS02955 Protein ID WP_015572580.1
Coordinates 621070..621357 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag N5929_RS02960 Protein ID WP_017694570.1
Coordinates 621344..621646 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5929_RS02930 (N5929_10825) 616163..616882 + 720 WP_023303034.1 winged helix-turn-helix domain-containing protein -
N5929_RS02935 (N5929_10820) 617032..617502 + 471 WP_023303035.1 MarR family transcriptional regulator -
N5929_RS02940 (N5929_10815) 617499..618566 + 1068 WP_026080654.1 HlyD family secretion protein -
N5929_RS02945 (N5929_10810) 618556..619632 + 1077 WP_015572578.1 DUF2955 domain-containing protein -
N5929_RS02950 (N5929_10805) 619629..620900 - 1272 WP_015572579.1 DUF445 domain-containing protein -
N5929_RS02955 (N5929_10800) 621070..621357 + 288 WP_015572580.1 BrnT family toxin Toxin
N5929_RS02960 (N5929_10795) 621344..621646 + 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
N5929_RS02965 (N5929_10790) 621675..622313 - 639 WP_015572581.1 LysE family translocator -
N5929_RS02970 (N5929_10785) 622352..623104 - 753 WP_015572582.1 AraC family transcriptional regulator -
N5929_RS02975 (N5929_10780) 623258..624628 + 1371 WP_017694568.1 NAD-dependent succinate-semialdehyde dehydrogenase -
N5929_RS02980 (N5929_10775) 624806..625351 - 546 WP_006810254.1 YfaZ family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T259003 WP_015572580.1 NZ_CP104689:621070-621357 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT259003 WP_017694570.1 NZ_CP104689:621344-621646 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References