Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1681623..1682239 Replicon chromosome
Accession NC_016804
Organism Mycobacterium bovis BCG str. Mexico

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag BCGMEX_RS07910 Protein ID WP_003407593.1
Coordinates 1681922..1682239 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7U4BU54
Locus tag BCGMEX_RS07905 Protein ID WP_011799188.1
Coordinates 1681623..1681925 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGMEX_RS07895 1677509..1679356 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
BCGMEX_RS07900 1679357..1681609 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
BCGMEX_RS07905 1681623..1681925 + 303 WP_011799188.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
BCGMEX_RS07910 1681922..1682239 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
BCGMEX_RS07915 1682236..1683240 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
BCGMEX_RS07920 1683293..1684582 + 1290 WP_003407599.1 serine hydrolase -
BCGMEX_RS07925 1684655..1685428 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
BCGMEX_RS07930 1685486..1685677 - 192 WP_003407609.1 dodecin family protein -
BCGMEX_RS22095 1685708..1685932 - 225 WP_160522526.1 NUDIX domain-containing protein -
BCGMEX_RS07940 1686202..1687230 + 1029 WP_011799189.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T25900 WP_003407593.1 NC_016804:1681922-1682239 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T25900 NC_016804:1681922-1682239 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11199.50 Da        Isoelectric Point: 9.5564

>AT25900 WP_011799188.1 NC_016804:1681623-1681925 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
VPFLVALSGIILGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT25900 NC_016804:1681623-1681925 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTTGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BU54

References