Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3207474..3208179 Replicon chromosome
Accession NZ_CP104681
Organism Escherichia coli strain 2022CK-00450

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag N5922_RS15805 Protein ID WP_000539521.1
Coordinates 3207474..3207860 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N5922_RS15810 Protein ID WP_001280945.1
Coordinates 3207850..3208179 (+) Length 110 a.a.

Genomic Context

N5922_RS15785N5922_RS15800N5922_RS15805N5922_RS15810N5922_RS15825N5922_RS15790N5922_RS15795N5922_RS15815N5922_RS15820N5922_RS15830
Location: 3203478..3204104 (627 bp)
Type: Others
Protein ID: WP_016241992.1
Location: 3205923..3207248 (1326 bp)
Type: Others
Protein ID: WP_000049367.1
Location: 3207474..3207860 (387 bp)
Type: Toxin
Protein ID: WP_000539521.1
Location: 3207850..3208179 (330 bp)
Type: Antitoxin
Protein ID: WP_001280945.1
Location: 3211217..3211914 (698 bp)
Type: Others
Protein ID: WP_103215986.1
Location: 3204101..3205216 (1116 bp)
Type: Others
Protein ID: WP_000555031.1
Location: 3205327..3205710 (384 bp)
Type: Others
Protein ID: WP_000497137.1
Location: 3208249..3209577 (1329 bp)
Type: Others
Protein ID: WP_000086877.1
Location: 3209585..3211162 (1578 bp)
Type: Others
Protein ID: Protein_3105
Location: 3211937..3212848 (912 bp)
Type: Others
Protein ID: WP_001236042.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N5922_RS15785 (3203478)3203478..3204104+627WP_016241992.1glutathione S-transferase GstB-
N5922_RS15790 (3204101)3204101..3205216-1116WP_000555031.1aldose sugar dehydrogenase YliI-
N5922_RS15795 (3205327)3205327..3205710-384WP_000497137.1biofilm formation regulator BssR-
N5922_RS15800 (3205923)3205923..3207248+1326WP_000049367.130S ribosomal protein S12 methylthiotransferase RimO-
N5922_RS15805 (3207474)3207474..3207860+387WP_000539521.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N5922_RS15810 (3207850)3207850..3208179+330WP_001280945.1DNA-binding transcriptional regulatorAntitoxin
N5922_RS15815 (3208249)3208249..3209577-1329WP_000086877.1GGDEF domain-containing protein-
N5922_RS15820 (3209585)3209585..3211162-1578Protein_3105cyclic diguanylate phosphodiesterase-
N5922_RS15825 (3211217)3211217..3211914+698WP_103215986.1IS1-like element IS1A family transposase-
N5922_RS15830 (3211937)3211937..3212848-912WP_001236042.1glutathione ABC transporter permease GsiD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T258992 WP_000539521.1 NZ_CP104681:3207474-3207860 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT258992 WP_001280945.1 NZ_CP104681:3207850-3208179 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A829GCT6

Antitoxin

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Source
ID
Structure
No matching records found

References