258992

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3207474..3208179 Replicon chromosome
Accession NZ_CP104681
Organism Escherichia coli strain 2022CK-00450

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag N5922_RS15805 Protein ID WP_000539521.1
Coordinates 3207474..3207860 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N5922_RS15810 Protein ID WP_001280945.1
Coordinates 3207850..3208179 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5922_RS15785 (3203478) 3203478..3204104 + 627 WP_016241992.1 glutathione S-transferase GstB -
N5922_RS15790 (3204101) 3204101..3205216 - 1116 WP_000555031.1 aldose sugar dehydrogenase YliI -
N5922_RS15795 (3205327) 3205327..3205710 - 384 WP_000497137.1 biofilm formation regulator BssR -
N5922_RS15800 (3205923) 3205923..3207248 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
N5922_RS15805 (3207474) 3207474..3207860 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5922_RS15810 (3207850) 3207850..3208179 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
N5922_RS15815 (3208249) 3208249..3209577 - 1329 WP_000086877.1 GGDEF domain-containing protein -
N5922_RS15820 (3209585) 3209585..3211162 - 1578 Protein_3105 cyclic diguanylate phosphodiesterase -
N5922_RS15825 (3211217) 3211217..3211914 + 698 WP_103215986.1 IS1-like element IS1A family transposase -
N5922_RS15830 (3211937) 3211937..3212848 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T258992 WP_000539521.1 NZ_CP104681:3207474-3207860 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT258992 WP_001280945.1 NZ_CP104681:3207850-3208179 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References