Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2548061..2548699 Replicon chromosome
Accession NZ_CP104681
Organism Escherichia coli strain 2022CK-00450

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N5922_RS12415 Protein ID WP_000813794.1
Coordinates 2548523..2548699 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N5922_RS12410 Protein ID WP_001270286.1
Coordinates 2548061..2548477 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5922_RS12390 (2543213) 2543213..2544154 - 942 WP_001251313.1 ABC transporter permease -
N5922_RS12395 (2544155) 2544155..2545168 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
N5922_RS12400 (2545186) 2545186..2546331 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
N5922_RS12405 (2546576) 2546576..2547982 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
N5922_RS12410 (2548061) 2548061..2548477 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N5922_RS12415 (2548523) 2548523..2548699 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N5922_RS12420 (2548921) 2548921..2549151 + 231 WP_000494244.1 YncJ family protein -
N5922_RS12425 (2549243) 2549243..2551204 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N5922_RS12430 (2551277) 2551277..2551813 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N5922_RS12435 (2551905) 2551905..2553080 + 1176 WP_016242090.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T258991 WP_000813794.1 NZ_CP104681:c2548699-2548523 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT258991 WP_001270286.1 NZ_CP104681:c2548477-2548061 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References