Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2548061..2548699 Replicon chromosome
Accession NZ_CP104681
Organism Escherichia coli strain 2022CK-00450

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N5922_RS12415 Protein ID WP_000813794.1
Coordinates 2548523..2548699 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N5922_RS12410 Protein ID WP_001270286.1
Coordinates 2548061..2548477 (-) Length 139 a.a.

Genomic Context

N5922_RS12420N5922_RS12435N5922_RS12390N5922_RS12395N5922_RS12400N5922_RS12405N5922_RS12410N5922_RS12415N5922_RS12425N5922_RS12430
Location: 2548921..2549151 (231 bp)
Type: Others
Protein ID: WP_000494244.1
Location: 2551905..2553080 (1176 bp)
Type: Others
Protein ID: WP_016242090.1
Location: 2543213..2544154 (942 bp)
Type: Others
Protein ID: WP_001251313.1
Location: 2544155..2545168 (1014 bp)
Type: Others
Protein ID: WP_000220399.1
Location: 2545186..2546331 (1146 bp)
Type: Others
Protein ID: WP_000047424.1
Location: 2546576..2547982 (1407 bp)
Type: Others
Protein ID: WP_000760626.1
Location: 2548061..2548477 (417 bp)
Type: Antitoxin
Protein ID: WP_001270286.1
Location: 2548523..2548699 (177 bp)
Type: Toxin
Protein ID: WP_000813794.1
Location: 2549243..2551204 (1962 bp)
Type: Others
Protein ID: WP_001301045.1
Location: 2551277..2551813 (537 bp)
Type: Others
Protein ID: WP_000429155.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N5922_RS12390 (2543213)2543213..2544154-942WP_001251313.1ABC transporter permease-
N5922_RS12395 (2544155)2544155..2545168-1014WP_000220399.1ABC transporter ATP-binding protein-
N5922_RS12400 (2545186)2545186..2546331-1146WP_000047424.1ABC transporter substrate-binding protein-
N5922_RS12405 (2546576)2546576..2547982-1407WP_000760626.1PLP-dependent aminotransferase family protein-
N5922_RS12410 (2548061)2548061..2548477-417WP_001270286.1type II toxin-antitoxin system antitoxin HicBAntitoxin
N5922_RS12415 (2548523)2548523..2548699-177WP_000813794.1type II toxin-antitoxin system mRNA interferase toxin HicAToxin
N5922_RS12420 (2548921)2548921..2549151+231WP_000494244.1YncJ family protein-
N5922_RS12425 (2549243)2549243..2551204-1962WP_001301045.123S rRNA 5-hydroxycytidine C2501 synthase-
N5922_RS12430 (2551277)2551277..2551813-537WP_000429155.1DNA-binding transcriptional regulator SutR-
N5922_RS12435 (2551905)2551905..2553080+1176WP_016242090.1BenE family transporter YdcO-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T258991 WP_000813794.1 NZ_CP104681:c2548699-2548523 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT258991 WP_001270286.1 NZ_CP104681:c2548477-2548061 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6HPB

Antitoxin

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Source
ID
Structure
No matching records found

References